🧵 Gabapentin and dopamine

Anonymous at Sun, 17 Mar 2024 19:17:46 UTC No. 16083352

I know Gabapentin and Pregabalin have all sorts of downstream effects... I'm aware they're VDCC inhibitors, not technically dopamine agonists or reuptake inhibitors, but does their mechanism of action at all raise dopamine levels or affect dopamine receptors?

Lots of people feel happier, energized, more social, and better at focus/executive function on the right dose (even if memory is famously impaired), which implies to me that it's not just slowing neurotransmitter activity across the board.

I'm trying to reduce my Adderall tolerance and restore my very-impaired dopamine function by taking a drug vacation wherever possible and wondering if being on a higher dose of Gabapentin is making recovery any worse.