🧵 Ketamine for ADHD / addictions / procrastination
Anonymous at Sun, 7 Apr 2024 19:10:00 UTC No. 16117349
Ketamine is one of the substances that reliably induces neuroplasticity in prefrontal cortex (PFC) and anterior cingulate cortex (ACC) among other regions. But PFC And ACC are the parts that's important for us. Ketamine has been studied for its potential treatment in addiction and shown promising results.
Amphetamine is also one of the well established to improve executive functioning, particularly for those with impairing-level executive dysfunction like ADHD and addiction.
So, let's say we start this protocol in Jan 1st.
Jan 1: ketamine 1mg/kg
Jan 2-10: therapeutic amphetamine (ADHD dose)
Jan 11: ketamine 1mg/kg
Jan 12-30: therapeutic amphetamine
Feb 1: ketamine 1mg/kg or 0.5mg/kg
Feb 2-20: therapeutic amphetamine
The idea is, use ketamine to induce "critical period" or neuroplasticity, and then during this critical period, force yourself to do the habit that is favourable (like quitting addictive behaviours, procrastination, impulsivity) such that we "change" the neural network's pathways during these vulnerable/plastic period. So once the ketamine is ceased, the neural pathway that was formed during this protocol remains intact. Basically using ketamine to smooth the process and make it faster, as an aid.
Think of it like creating a jewelry. You have a golden chain, but you want a bracelet. So you melt that chain (equivalent to administering ketamine), and then it becomes more "plastic" (meaning vulnerable to change, think of this as doing the activity you flavour during this period). But this is temporary, you have to create the shape within a few hours of melting that chain. Once you melted the golden chain and created a bracelet out of it, now you can make it cool down and now you got yourself a bracelet out of chain.
Previous neural pathway was impulsive, addictive, procrastinating (maladaptive), now you induce ketamine, with or without amphetamine, then at end of protocol, you have new neural pathways that is favourable.
Any thoughts? Discuss.
Anonymous at Sun, 7 Apr 2024 19:18:38 UTC No. 16117360
>>16117349
they've been trying to brainwash people for generations, I'm sure the potentiality of all these substances has been exhausted. if it worked reliably, they'd be putting it in all your food.
https://odysee.com/@Realfake_Newsou
Anonymous at Sun, 7 Apr 2024 19:28:06 UTC No. 16117379
>>16117349
Flooding your brain with these chemicals ends up only increasing the number of neuro-receptors. Once you're off that stuff, you will suffer an instantaneous and severe deficiency in whatever chemical you used to ingest. At the very best, you're just trying to copy Pavlov's experiment by givng yourself a high whenever you did something "good". In this sense, beating your addiction by getting high whenever you abstained from getting high on the other drug is just idiotic.
Anonymous at Sun, 7 Apr 2024 19:35:57 UTC No. 16117385
>>16117379
>beating your addiction by getting high
That's not what I'm saying, retard. Re-read it. I'm not talking about "getting high".
Anonymous at Sun, 7 Apr 2024 20:50:41 UTC No. 16117458
Do people who used ADHD drugs to get stuff done stay more productive after cessation? Or do they revert to how they were before?
Anonymous at Sun, 7 Apr 2024 21:25:03 UTC No. 16117492
>>16117458
They generally revert back to previous state. Amphetamine basically increases activity in PFC, giving more cognitive control and improved executive functioning. To retain some benefits after cessation of amphetamine, we should create structured pattern and behavoural interventions while on the drug (like creating calendars, setting up todo list softwares, creating schedules and patterns that we should force ourself to follow upon cessation of amphetamine. So in a way, some people can use amphetamine to "teach" your brain. Of course, everyone's different.
Anonymous at Sun, 7 Apr 2024 22:08:18 UTC No. 16117553
>>16117349
>ADHD
>depression
These and related conditions stem from a poor gut microbiome. Serotonin and dopamin are metabolites from bacteria in our gut.
>Gut bacteria and mind control
https://www.youtube.com/watch?v=mio
Anonymous at Mon, 8 Apr 2024 07:16:54 UTC No. 16118237
>>16117379
You have clearly no understanding of psychopharmacology and the homeostatic response to one of the drugs is the exact opposite to what you asserted and one means OP is trying to use. He didn't say a word about being addicted to a substance. An intelligent person sees that and assumes addiction foremost pertains to internal modes and behaviors. Shoo off now and go indulge your libido and your stomach, clearly not addictions according to midwits because duh everyone does it, and God forbid someone finds something more euohoric (not even what OP proposed again) because uhhh that's idiotic okay. Worthless post from a worthless mind.
>>16117553
Peripheral serotonin and dopamine do not cross the BBB.
Anonymous at Mon, 8 Apr 2024 09:43:33 UTC No. 16118337
>>16117349
I would go with shrooms instead of Ketamine, it's already verified and good enough for me.
Anonymous at Mon, 8 Apr 2024 17:23:20 UTC No. 16118979
>>16118337
> it's already verified and good enough for me.
It's not "verified" for ADHD at all.
Anonymous at Mon, 8 Apr 2024 17:42:55 UTC No. 16119042
>>16118237
>Peripheral serotonin and dopamine do not cross the BBB
>therefore a poor gut microbiome isn't involved
Horseshite oversimplification.
Anonymous at Mon, 8 Apr 2024 17:45:07 UTC No. 16119052
>>16117349
Props for an interesting and relevant threads but what you're describing is just done with amphetamines alone.
If ketamine+amphetamines could actually CURE ADHD that would really be something.
As is, my biggest hope is TMS
Anonymous at Tue, 9 Apr 2024 09:27:01 UTC No. 16120628
>>16118237
>Peripheral serotonin and dopamine do not cross the BBB
>Although serotonin has intrinsic roles in the intestines and peripheral metabolism, it is capable of locally activating afferent nerve endings that are connected directly to the central nerve system
Anonymous at Tue, 9 Apr 2024 09:59:55 UTC No. 16120645
>>16118979
>It's not "verified" for ADHD at all.
Do we even know ADHD exists? Currently, it's just an extremely vague list of disliked behavioral traits.
Anonymous at Tue, 9 Apr 2024 12:07:47 UTC No. 16120744
>>16117492
>ike creating calendars, setting up todo list softwares
lmao, that shit rarely works. It's hard to describe but trying to maintain todo lists and calendars feels like the mental equivalent of running through a kiddy pool full of taffy while someone scratches their nails on a chalkboard, assuming you don't forget about it entirely.
Schedules and patterns on the other hand, that can work. It takes a lot of long-term repetition to get it really drilled into your brain but having solid repeatable routines can be a really big help, as can having physical items kept in constant locations that they must always be returned to.
I've never been able to relate to other ADHD folks saying things like "lost my house keys for the third time this year, sigh, so ADHD". Like come on nigger how fucking hard is it to keep the damn things in your pocket when out of the house or to summon your last reserves of willpower to put them back where they belong when you get home. Do these idiots just disgorge the contents of their pockets wherever and whenever?
Anonymous at Tue, 9 Apr 2024 12:32:27 UTC No. 16120770
>>16117349
I hardly visit /sci/ but it's so cool to see a neuropsychopharmacology-related thread!
It's a really interesting hypothesis and I wonder if anyone has gotten around to testing it or something along a similar route (e.g., swapping ketamine for psilocybin, or amphetamine for modafinil).
Also, my two cents would be including some form of psychological guidance towards the right habits. I do understand that ultimately only you can really help yourself, but sometimes forcing yourself to do the right thing is challenging. So maybe even if you don't introduce a therapist (god i hate that word) into the setup, even a friend as an accountability partner could be enough to achieve the desired results.
(following this thread - hope it doesn't die)
Anonymous at Tue, 9 Apr 2024 13:31:29 UTC No. 16120826
>>16120770
>but it's so cool to see a neuropsychopharmacology-related thread!
Hey kids. Did you know that drugs are bad until they're not?
It all depends on your pharma-funded psychiatrist! It's all about helping you.
Noo... it's not drug that Adderall is addictive and causes heart-related circulatory problems.
Anonymous at Tue, 9 Apr 2024 16:58:50 UTC No. 16121034
>>16120645
> it's another one of those retards
Because ADHD is LITERALLY A PHYSIOLOGICAL MALFUNCTION WHICH WE CAN LITERALLY FUCKING SEE and because stimulants calm you down instead of stimulate you.
Do you also want a proof of Earth being round? Get the fuck out of this board back to pol
Anonymous at Tue, 9 Apr 2024 17:01:15 UTC No. 16121041
>>16120744
I've been keeping a journal for like 10 years now and tried all kinds of organizational structures and to-do lists but at the end of the day YOU STILL HAVE ADHD AND GOOD LIKE DOING FUCKING ANYTHING.
Without them it would probably be even worse though
Anonymous at Tue, 9 Apr 2024 17:02:27 UTC No. 16121046
>>16120826
>>16120776
Welp it was fun before the inevitable invasion by a local schizo
Anonymous at Tue, 9 Apr 2024 18:19:55 UTC No. 16121140
>>16121034
>Because ADHD is LITERALLY A PHYSIOLOGICAL MALFUNCTION WHICH WE CAN LITERALLY FUCKING SEE
No, we can't. If we could, you would have been referred to a neurologist for a brain scan which would have isolated the dysfunction in question.
>because stimulants calm you down instead of stimulate you.
Stimulants calm down anyone at low concentrations. It's why amphetamines were given to soldiers. You just repeat a fairy tale invented and propagated by pharmaceutical PR companies.
Anonymous at Tue, 9 Apr 2024 19:05:23 UTC No. 16121217
>>16121034
>and because stimulants calm you down instead of stimulate you.
Kekus, imagine literally believing that amphetamine has different effects on those with ADHD and "neurotypicals"