🧵 Repeated withdrawal
Anonymous at Wed, 1 May 2024 20:32:40 UTC No. 16155263
Okay, say you become physically dependent on caffeine, then you stop drinking for long enough for withdrawals to kick in, then you drink it again, is it possible to get used to this and is there any benefits to it?
You hear about "detox" and all of that other stuff where people stop doing things for a few days / weeks to "detox" themselves, but what does the actual science say on giving yourself a break from this and then using it again after a couple days? It's strange this isn't talked about more, is there some kind of neurological benefit or demerit to repeatedly going through physical dependence?
Anonymous at Wed, 1 May 2024 21:33:52 UTC No. 16155353
>>16155263
Caffeinism is far more common that people thinks.
The worst withdrawal I had was a terrible headache that only lasted 2-3 days. Gradual reduction is better and you don't need remove all caffeine. 100 mg / day or less should be sufficient.
Anonymous at Wed, 1 May 2024 23:25:14 UTC No. 16155507
>>16155263
Your receptors are regulated because of you drinking coffe and activating too much volts on them, so you got used to it.
Anonymous at Wed, 1 May 2024 23:30:49 UTC No. 16155512
Anonymous at Thu, 2 May 2024 04:21:14 UTC No. 16155878
>All four adenosine receptor subtypes undergo agonist-induced desensitization and trafficking, but with somewhat different time frames and possibly distinct mechanisms [https://link.springer.com/article/
Biochemistry can't give a straight answer but it looks like they're trying. If the relevant time constant was a few hours like they claim for internalization of A1, overnight would feel like a longer holiday.
>>16155353
Subjectively, 50 mg daily does half or a quarter of what 500 mg daily does.
Anonymous at Thu, 2 May 2024 09:51:58 UTC No. 16156223
Caffeine withdrawal is worse nicotine and opioid withdrawals. It is marked by an excruciating headache that persists for days and lethargy and paradoxical insomnia. Nicotine withdrawal is short lived, a slight headache, impulsive controlets feel angrier on it, but in reality it's a mild transient frustration. Opioid withdrawal is the most over hyped thing in the world, you get the heckin sniffles and body aches and things feel a bit lackluster, libido is increased (negative if you're high IQ). Still better than a fucking headache.
As for the premise, there's some literature examining the effects of withdrawals and whether it can confer a benefit but it's sparse. There was one meta paper looking at the immunological effects of opioids and they found hundreds of studies on given drugs and their effects on the immune system but only 10 studies looking specifically at withdrawals. Perhaps search for acute effects of withdrawal or biochemical mechanisms of acute withdrawal for caffeine.
Anonymous at Thu, 2 May 2024 09:57:50 UTC No. 16156228
>>16156226
>what are outliers
now let's see the averages
Anonymous at Thu, 2 May 2024 10:00:52 UTC No. 16156231
I have been consuming caffeine every single day for the last 15 years without exception and I feel perfectly fine.
Anonymous at Thu, 2 May 2024 10:04:36 UTC No. 16156232
>>16156226
She drank 1 to 2 glasses of wine a day. Not 20 soijak beers every Friday night. Drinking like most people do ages you worse than anything else.
Anonymous at Thu, 2 May 2024 10:16:56 UTC No. 16156242
>>16156226
what if
our beliefs about what constitutes a healthy diet are in fact pure nonsense
Anonymous at Thu, 2 May 2024 10:19:16 UTC No. 16156248
>>16156242
not really nonsense, she's clearly an outlier, my post was tongue in cheek (largely but not fully).