🧵 sexual dimorphism of pain

Anonymous at Tue, 4 Jun 2024 11:04:21 UTC No. 16209550

males and females have different pain pathways activated by different hormones, proved across species

>female, but not male, mice were selectively sensitized by exposure to prolactin
>orexin B produced sensitization of male, but not female, mouse, macaque, and human dorsal root ganglion neurones.
Nociceptors are functionally male or female: from mouse to monkey to man
https://academic.oup.com/brain/advance-article-abstract/doi/10.1093/brain/awae179/7686987