🧵 Untitled Thread
Anonymous at Sat, 27 Jul 2024 04:39:36 UTC No. 16298438
I made a synthesis of DL-Phe from 1-napthol.
I have no reason to believe this is useful in any way. I also am unsure if it would actually work. It's based on a combination of simulator outputs and journal articles, all of which work generically, but I don't have the formal education to know if there are side reactions or if some of the groups are deactivating in this instance, or if the usual workups are inapplicable.
It is entirely the product of a deranged mind with too much time available.
Anonymous at Sat, 27 Jul 2024 04:43:15 UTC No. 16298443
you sure do seem to like talking about yourself on social media
Anonymous at Sat, 27 Jul 2024 04:51:42 UTC No. 16298453
It's still less deranged than 90% of this board these days.
Anonymous at Sat, 27 Jul 2024 14:33:46 UTC No. 16298954
>>16298438
5. the mCPBA will oxidize the amine
8. check if DMP is compatible with acids
9. the mCPBA will oxidize the amine
10-11. unnecessary, just hydrolyze the aldehyde
12. NaOH is the wrong type of base to use
13. AcO is not the best protecting group to use
B+, good effort though
Anonymous at Sun, 28 Jul 2024 11:16:50 UTC No. 16300224
>>16298954
What would a better protecting group be? Something bulkier?
Anonymous at Sun, 28 Jul 2024 12:47:05 UTC No. 16300304
>>16298438
In these cases I always recommend that the OP does a flip and so that is my recommendation for you as well
Anonymous at Sun, 28 Jul 2024 14:33:30 UTC No. 16300421
>>16298438
Do you set up that can do this reaction?
Anonymous at Sun, 28 Jul 2024 17:37:49 UTC No. 16300580
>>16300224
Frankly, I don't think you need a protecting group at all for the acid. The phenol should react preferentially. But if you're concerned about it (like you should be in step 8), you generally esterify with methanol.
For step 13, I'd be more concerned about that free amine, which will definitely react with the triflyl group first.
Anonymous at Sun, 28 Jul 2024 18:03:16 UTC No. 16300609
>>16298438
I drew a nice scheme for a shorter pathway, but this site is cooked, so I put it here instead https://files.catbox.moe/ubq600.png
Anonymous at Mon, 29 Jul 2024 01:42:38 UTC No. 16301251
>>16298438
>>16298954
what is? like is this biochemistry? I have no idea but I want to understand to play with simulators and read journal articles as well
>t. CS Econ
Anonymous at Mon, 29 Jul 2024 01:57:54 UTC No. 16301274
>>16301251
NTA but this is chemical synthesis, the reagents used are fairly common laboratory reagents.
Phenylalanine is an amino acid but it is also an amphetamine precursor and a building block for several drugs.
Anonymous at Mon, 29 Jul 2024 01:59:55 UTC No. 16301276
>>16300580
Triflate is pretty strong though, so being preferential may not help much. I know there's also a classical phenol reduction with zinc powder, but I don't know if that'd be compatible with the rest of the molecule.
>>16300609
Any way to make that chiral?
Anonymous at Mon, 29 Jul 2024 02:08:20 UTC No. 16301286
https://www.organic-chemistry.org/p
Protecting group compatibilities
Anonymous at Mon, 29 Jul 2024 06:52:53 UTC No. 16301502
>>16301276
>Any way to make that chiral?
Not directly I think, but you can go via an Erlenmeyer-Plöchl azlactone synthesis https://files.catbox.moe/k46g1e.png
Anonymous at Mon, 29 Jul 2024 09:15:56 UTC No. 16301571
>>16301502
The third reaction could also be done directly from the acid chloride stage by the Rosenmund reaction, or even directly from the carboxylic acid using a more exotic reaction described in 2019 by an AZn team.
Anonymous at Mon, 29 Jul 2024 11:21:32 UTC No. 16301667
>>16301571
>Rosenmund
True, I forgot about that one.
> more exotic reaction described in 2019 by an AZn team
I found Org. Lett. 21(19), 7713-7716 (2019), a single step with Re2(CO)10. That one or do you mean a different publication?
Anonymous at Mon, 29 Jul 2024 11:29:48 UTC No. 16301675
>>16298438
Now do world a favor and make some synthesis of P2P from things that are in the hardware store.
Anonymous at Mon, 29 Jul 2024 16:55:16 UTC No. 16302013
>>16301675
>DUDE TV SHOW LMAO
Anonymous at Mon, 29 Jul 2024 17:12:32 UTC No. 16302032
>>16302013
P2P in my country was available in "education accessories" but they banned it when one stupid show came up.
Fuck TV Shows, literally.
Anonymous at Mon, 29 Jul 2024 17:56:07 UTC No. 16302091
>>16302032
>P2P in my country was available in "education accessories"
Wew, tell me more.
Anonymous at Mon, 29 Jul 2024 18:57:46 UTC No. 16302199
>>16301667
I was actually looking at https://www.organic-chemistry.org/a
Anonymous at Mon, 29 Jul 2024 19:09:19 UTC No. 16302233
>>16301675
They've actually banned toluene in a number of states, and other chains have stopped selling it, switching to xylene. Which majorly complicates any synthesis, since they don't sell benzene either.
Anonymous at Mon, 29 Jul 2024 19:45:01 UTC No. 16302294
>>16301675
I don't know about the hardware store, but if you can get some phenol you can combine it with a halogen acid to get it halide, then combine with magnesium to get a Grignard reagent, which combined with propylene oxide gets you 1-phenyl-2-propanol, which is easily oxidized to P2P.
🗑️ Anonymous at Mon, 29 Jul 2024 19:53:56 UTC No. 16302311
how to make lsd at home?
Anonymous at Mon, 29 Jul 2024 20:46:21 UTC No. 16302393
>>16302233
We really are being treated like cattle here.
Anonymous at Mon, 29 Jul 2024 22:47:45 UTC No. 16302534
>>16302393
Home chemistry is increasingly being made functionally illegal, if it isn't already. Texas even regulates lab glassware.
Anonymous at Mon, 29 Jul 2024 23:01:37 UTC No. 16302547
>>16302233
wouldn't it be simpler to just ban all druggies? and by ban, I mean kill?
Anonymous at Tue, 30 Jul 2024 01:45:08 UTC No. 16302680
>>16301251
> not one enzyme in the reaction scheme
> "is this biochemistry?"
you are not ready anon
Anonymous at Tue, 30 Jul 2024 04:02:45 UTC No. 16302813
>>16302294
Lol, good luck keeping your grignard dry and free of oxygen, your yield will be shit.
Anonymous at Tue, 30 Jul 2024 07:58:08 UTC No. 16302938
>>16302199
Interesting, thanks.
>>16302294
>phenol you can combine it with a halogen acid to get it halide
Aromatics don't do simple SN1 or SN2. Phenol does not behave like a normal alcohol. This doesn't work.
Anonymous at Tue, 30 Jul 2024 09:01:06 UTC No. 16302974
>>16302233
Here they sell it denaturalized at hardware store, but only to registred companies.
Anonymous at Tue, 30 Jul 2024 09:02:22 UTC No. 16302976
>>16302294
What about pyrolysing benzyl-ethyl with acetone in salty solution?
Anonymous at Tue, 30 Jul 2024 09:03:30 UTC No. 16302978
>>16302813
Innert atmosphere + anti-humidity substance which creates perciprate with water.
Anonymous at Tue, 30 Jul 2024 14:16:46 UTC No. 16303280
>>16302938
Can a more aggressive agent like PCl5 do it?
Anonymous at Tue, 30 Jul 2024 14:53:45 UTC No. 16303341
>>16302978
lol @ yur naivety
Anonymous at Tue, 30 Jul 2024 15:27:50 UTC No. 16303381
>>16303280
It would be easier to use EAS to get bromobenzene.
Anonymous at Tue, 30 Jul 2024 15:51:18 UTC No. 16303392
>>16303381
We have steps from benzal chloride, not bromo benzene, it's the same?
Anonymous at Tue, 30 Jul 2024 21:38:34 UTC No. 16303731
>>16298443
thielbot post
Anonymous at Tue, 30 Jul 2024 22:23:35 UTC No. 16303802
>>16303392
Just use AlCl3 instead of FeBr3, what is the motivation for using chlorobenzene? Bromoalkanes or other bromine compounds tend to be more selective in some reactions.
Anonymous at Tue, 30 Jul 2024 22:26:45 UTC No. 16303806
>>16303802
>>16303392
Sorry, I misread. This was originally in response to >>16302294
Benzal chloride is a different molecule but wasn't mentioned in that proposed synthesis.
Anonymous at Wed, 31 Jul 2024 04:47:00 UTC No. 16304210
>>16303806
https://pubs.rsc.org/en/content/art
https://open.bu.edu/bitstream/handl
Trully, but somehow I remember that benzal chloride to cyanide, and them something with HgAl to get the product.
Anonymous at Wed, 31 Jul 2024 14:45:25 UTC No. 16304657
>>16298438
Wtf is that? Will it make me high?
Anonymous at Wed, 31 Jul 2024 16:26:05 UTC No. 16304734
>>16304657
It's an amino acid
Anonymous at Thu, 1 Aug 2024 06:31:37 UTC No. 16305577
bump