Anonymous at Wed, 31 Jul 2024 15:34:14 UTC No. 16304689

And i just hope nobody here is dumb enough to think i mean to get naturally high all the time.

If i wanted to be high all the time, i'd buy weed. It's legal now.

What i'm interested in is seeing if my desire to use weed can be ameliorated by enhancing the natural pathway i am attempting to enhance with a drug.

Anonymous at Wed, 31 Jul 2024 18:12:12 UTC No. 16304827

>>16304686
idk people say mango enhances weed high, maybe look into that

Anonymous at Wed, 31 Jul 2024 21:15:09 UTC No. 16305007

>>16304689
The receptors are designed to receive those compounds and release neurotransmitters.
Interesting question is how did we develop cannabinoid and nicotine receptors in the first place? Or how did plants evolve to have those compounds that have receptors in humans and other organisms?
>>16304827
Some of the best weeds I smoked smelt mango lol

Anonymous at Wed, 31 Jul 2024 21:25:04 UTC No. 16305019

>>16305007
you're a drug addict

Anonymous at Thu, 1 Aug 2024 11:08:49 UTC No. 16305732

>>16304689
>What i'm interested in is seeing if my desire to use weed can be ameliorated by enhancing the natural pathway i am attempting to enhance with a drug.
In other words you just want to be high all the time without depending on a plant to do it.

Anonymous at Thu, 1 Aug 2024 14:03:44 UTC No. 16305836

>>16305732

Nuuuuu gahd dammit!

I have weed right here. It's vape weed. I can smoke it 24/7. I can smoke at work. I can smoke it right next to a cop and he will assume it's a nicotine vape pen.

I smoke it so often that i've started running experiments to undo weed tolerance chemically.

There is something in salad which does it. I'm not sure yet. Might be multiple chemicals. Choline has something to do with it.

But then i thought, "Hey, maybe instead of getting high literally all the time, i could figure out how to enhance the natural pathway to produce the normal version of these chemicals."

It didn't occur to me until choline helped. Because choline is used to produce acetylcholine, the famous neurotransmitter. So perhaps if i was low in that, i could be low in other neurotransmitters.

Anonymous at Thu, 1 Aug 2024 14:14:45 UTC No. 16305846

Answer

Your curiosity about the endocannabinoid system (ECS) and its interaction with cannabinoids like THC and CBD is fascinating! Let's delve into the pathways involved and the nutrients that can support the natural production of endocannabinoids.
Overview of the Endocannabinoid System

The ECS consists of:

CB1 Receptors: Primarily found in the brain and central nervous system, these receptors are involved in regulating mood, memory, pain, and appetite.
CB2 Receptors: Located mainly in the peripheral nervous system and immune cells, these receptors play a role in inflammation and immune response.

Endocannabinoids are naturally occurring compounds in the body that bind to these receptors. The two primary endocannabinoids are:

Anandamide (AEA): Often referred to as the "bliss molecule," it is involved in mood regulation, pain, and appetite.
2-Arachidonoylglycerol (2-AG): This endocannabinoid is more abundant and plays a role in various physiological processes.

Pathway of Endocannabinoid Production

The production of endocannabinoids involves several steps:

Synthesis: Endocannabinoids are synthesized from membrane phospholipids in response to various stimuli (e.g., stress, pain).
Release: Once synthesized, they are released into the synaptic cleft, where they can bind to CB1 and CB2 receptors.
Degradation: After their action, endocannabinoids are broken down by enzymes (e.g., fatty acid amide hydrolase for AEA and monoacylglycerol lipase for 2-AG).

Nutrients That Support Endocannabinoid Production

Anonymous at Thu, 1 Aug 2024 14:15:46 UTC No. 16305849

>>16304686
To enhance the natural production of endocannabinoids, consider the following vitamins, minerals, and nutrients:

Omega-3 Fatty Acids:
Sources: Fatty fish (salmon, mackerel), flaxseeds, walnuts.
Role: Omega-3s are precursors to endocannabinoids and can enhance their production.

Omega-6 Fatty Acids:
Sources: Vegetable oils (sunflower, corn), nuts, seeds.
Role: These fatty acids are also involved in the synthesis of endocannabinoids, particularly arachidonic acid, which is a precursor for 2-AG.

Choline:
Sources: Eggs, liver, basedbeans, and cruciferous vegetables.
Role: Choline is essential for cell membrane integrity and may influence the synthesis of endocannabinoids.

Magnesium:
Sources: Leafy greens, nuts, seeds, whole grains.
Role: Magnesium plays a role in neurotransmitter function and may support the ECS.

Zinc:
Sources: Meat, shellfish, legumes, seeds, nuts.
Role: Zinc is involved in various enzymatic processes and may influence the ECS.

B Vitamins:
Sources: Whole grains, meat, eggs, dairy, legumes.
Role: B vitamins (especially B6, B12, and folate) are crucial for overall brain health and neurotransmitter synthesis.

Antioxidants:
Sources: Fruits and vegetables (berries, citrus, leafy greens).
Role: Antioxidants can help protect the ECS from oxidative stress, potentially enhancing its function.

Anonymous at Thu, 1 Aug 2024 14:18:01 UTC No. 16305853

>>16305849

Damn. Well i've done all that.

Anonymous at Thu, 1 Aug 2024 14:20:35 UTC No. 16305856

Hmm. Perhaps the anandamine can explain the anomalous level of benefit chocolate gives.

Anonymous at Thu, 1 Aug 2024 14:36:36 UTC No. 16305877

>>16304686
When we talk about thc and cbd and all cannabinoids in weed synthetic stuff included we’re talking about supraphysiological molecules. If you wanted to achieve that same level stimulation of your cb1 and cb2 receptors, it would be impossible with endocannabinoids. Maybe if you starve yourself for a week or two and you eat you feel some high other than feeling sick idk. Id just buy weed.

Anonymous at Thu, 1 Aug 2024 14:37:31 UTC No. 16305878

>>16305877

I don't want to achieve the same level of stimulation. I don't want to get high. I want to get normal.

Anonymous at Thu, 1 Aug 2024 14:39:06 UTC No. 16305883

I think my receptors are downregulated or the pathway for their neurotransmitters are downregulated. And i wanna know how to upregulate it. Without getting high. God dammit.

Anonymous at Thu, 1 Aug 2024 14:44:59 UTC No. 16305885

>>16305883
Eat healthy fats, do exercise and avoid stress. Also T break helps a lot, but if you smoke a lot it takes weeks or months to remove brain fog completely and be back on track. Also weed is strongly estrogenic. Good luck

Anonymous at Thu, 1 Aug 2024 14:48:22 UTC No. 16305889

>>16305885

Interestingly i find that taking choline ameliorates brain fog greatly.

I think the weed is somehow depleting it.

I've been working on undoing weed tolerance. I understand that the prevailing theory is that continuous use changes the expression of the receptors in an attempt to maintain homeostasis, but i am testing the possibility that it's actually caused by a deficiency.

I think it might be like vitamin C. In that the damage it does slowly accumulates over time and it takes months for it to actually show symptoms(inability to get high).

Anonymous at Fri, 2 Aug 2024 13:53:56 UTC No. 16307047

Bump for first not cringe post in few days

Anonymous at Fri, 2 Aug 2024 13:54:58 UTC No. 16307049

>>16305889
Dark chockolate with onions lecithin is your friend.

Anonymous at Fri, 2 Aug 2024 14:18:17 UTC No. 16307071

>>16307049
*s*o*y* lecithine, I hope I didn't get this word replace virus in computer again

Why is this board censoring that word?

Anonymous at Sat, 3 Aug 2024 16:39:33 UTC No. 16308630

>>16307071

It's not censorship, it's trolling.

The word filters are usually implemented to troll someone. Like that time to filtered femanon to cumdumpster.

Basically there was this big annoying vegan movement about onions products and the admins decided to troll them a little with basedbean and onions.

Anonymous at Sat, 3 Aug 2024 16:55:07 UTC No. 16308650

>>16307071
>>16308630
>word filters

Anonymous at Sun, 4 Aug 2024 13:20:23 UTC No. 16309708

>>16307049

I had noticed that very very strangely that reeses peanut butter cups, specially the dark chocolate thins, helped. I was losing my mind trying eating every ingredient in the thing looking for which one is causing the effect.

Anonymous at Mon, 5 Aug 2024 15:36:50 UTC No. 16310969

Also very strangely, carrots help for some reason.