🧵 Tardive psychosis thread
Anonymous at Wed, 16 Oct 2024 07:26:41 UTC No. 16434040
Everyone’s favourite topic
How can long term use of the following NOT induce psychosis?
>d2 antagonists
>a1 adrenergic antagonists
A1b at least mediates excitatory NMDAR expression, antagonists have shown anticonvulsant and gonadotoxic activity
>5ht2a/2b antagonists
5ht2b regulates dopamine uptake, with agonists such as guanfacine showing temporary “improvement ” of executive function
Is it all a lie to make people docile and dependent? Bonus points for mechanism-based arguments
Anonymous at Wed, 16 Oct 2024 14:00:48 UTC No. 16434388
>>16434040
take your meds psychosis-chan
Anonymous at Wed, 16 Oct 2024 21:33:06 UTC No. 16435254
>>16434040
oh boy, another schizo thread!
Anonymous at Fri, 18 Oct 2024 03:37:43 UTC No. 16437399
Anonymous at Fri, 18 Oct 2024 04:04:17 UTC No. 16437415
How much loss is corelative to age at time of study and length of study. How much "loss" is actual loss and not apparent loss due to reduced bloodflow and thus water volume. Is the effect recoverable at cessation, and how much?
I have a lot of questions I think you don't have answers for.
Anonymous at Fri, 18 Oct 2024 06:35:05 UTC No. 16437504
>>16437415
It depends on factors such as how much thiamine is in your diet.
Antipsychotics only antagonize d2-like receptors at relevant concentrations which puts the brain into an excitatory state.
Yes it is recoverable, just like alcohol abuse, with necessary nutrition.
Picrel. Add some nicotinic acid (nutritional yeast)
Anonymous at Fri, 18 Oct 2024 11:32:12 UTC No. 16437714
>>16437504
add high-dose glycine and maybe NAC
Anonymous at Fri, 18 Oct 2024 12:03:52 UTC No. 16437754
>>16437504
Yes, but somehow glutamate is inhibited when D1 and D2 are occupied at the same time... Therefore it makes you not have inhibition an fry up your brain being unable to be satisfied.
Anonymous at Fri, 18 Oct 2024 12:04:52 UTC No. 16437758
>>16434040
Long term use of that induce psychosis, but you're too fucking tired, so it doesn't end up like domestic terrorism.
Anonymous at Fri, 18 Oct 2024 12:07:23 UTC No. 16437760
>>16434040
The gist is that antipsychotics cause brain damage but that is preferable to full blown schizophrenia, in the sense that it prolongs life (Full blown schizophrenia will either get you killed or an hero). People that are still normal enough to work and perform in society should not take them.
Anonymous at Fri, 18 Oct 2024 12:07:48 UTC No. 16437761
>>16437714
I'll add some supplements, it's not so simple. Like something that modulates BDNF + something that produces it... Like NSI-189 + Liposomal apigenin/apigenin 7 glycosis.
Anonymous at Fri, 18 Oct 2024 12:09:16 UTC No. 16437764
Haloperidol induces a sixfold increase in levels of ROS, which are generated from mitochondria.
Holy fucks, I guess others do that too, I would suggest some strong antioxidants.
Anonymous at Sat, 19 Oct 2024 17:55:14 UTC No. 16440053
>>16434040
retardive psychosis.
Anonymous at Sun, 20 Oct 2024 01:22:04 UTC No. 16440575
>>16434040
too much dopamine, serotonin or too little nmda, cause psychosis.
this is why anti-psychotics reverse the hallucinations of mushrooms, lsd, meth and so on.
Anonymous at Sun, 20 Oct 2024 01:23:10 UTC No. 16440578
>>16440575
and why ketamine causes psychosis
you won't get psychosis from anti-psychotics. that's the point.
Anonymous at Sun, 20 Oct 2024 11:54:49 UTC No. 16441057
>>16440575
And that's bullshit, anti-psychotic dose on hallucinogen is making subject live in hell for a two or three days, it's better to let it wear of on diazepam, and if hallucinations persist, then give anti-psychotics.
>>16440578
Anti-psychotics make up for psychosis, because psychosis is basically too much useless long term potentiation caused by glutamate, and that's what happens if you block D2 receptor, because with simulatneus activation of D1/D2 receptor, lowers glutamate transimission. Anti-psychotics makes this transmission being really heavy. So you can't ever be satisfied, if you're smoker you need more smokes. If you're drug addict, your cravings would be stronger.
Anonymous at Sun, 20 Oct 2024 13:22:29 UTC No. 16441144
>>16434040
You're right. This is my favorite topic
Thanks for the thread and not ironically so bump