Anonymous at Fri, 18 Oct 2024 12:25:13 UTC No. 16437787

>>16437664
Like most drugs, opiates are a natural drug already found in the body and in plants. Drug research is often just copying body chemicals.

Anonymous at Fri, 18 Oct 2024 13:44:04 UTC No. 16437889

Did you remember anti-drug saying that cannabis is gateway of hell? You can walk straight out of opiods using cannabis. It's not unidirectional gate...

Anonymous at Fri, 18 Oct 2024 15:38:45 UTC No. 16438098

>>16437664
they're the most powerful painkiller there is and there's nothing wrong with them. issues only arise when retards try to use them to get high.

Anonymous at Fri, 18 Oct 2024 16:08:16 UTC No. 16438139

>>16437664
>Isnt there some electrical impulse device than can dampen pain?
Spinal cord stimulators is the search term you want. They are like pacemakers in that they are surgically implanted devices that give electrical shocks to the spinal cord to break up pain signaling. They are imperfect in that if the same doctor implanted the same device in the same patient it would perform slightly differently each time. The nervous system it just that fine and we really know next to nothing about pain. They tend to be used only when other treatments fail to provide relief.
Opiates are preferred by doctors in that they are easy to tweak. Just vary the dosage or the "blend" with other meds (e.g. Vicodin). And they are non-surgical.

Anonymous at Sun, 20 Oct 2024 01:45:13 UTC No. 16440606

>>16438098
>they're the most powerful painkiller there is
>there's nothing wrong with them
Pick 1

Anonymous at Sun, 20 Oct 2024 02:00:58 UTC No. 16440636

>>16438139
TENS/EMS units are the topical OTC version of this. They work decently well and can build muscle somewhat.

Anonymous at Sun, 20 Oct 2024 02:12:21 UTC No. 16440650

>>16437664
Yeah because damn monkey brains couldn't handle it and got addicted

Anonymous at Sun, 20 Oct 2024 13:11:56 UTC No. 16441130

>>16437889
Problem is most opioid users already smoke, and once you get used to weed it’s back to the opioids.
>>16438098
> issues only arise when retards try to use them to get high.
Recommended dose gets you high, it’s supposed - that’s how analgesics work, then people naturally start seeking out what made them feel good as the drug compromised their frontal cortex and threw their neurochemistry out of balance.
Funny how you retards provide a free will argument to defend your drugs but you’re all so quick to deny it when it could potentially impact your income.
Your condescending argument doesn’t work nigga

Anonymous at Sun, 20 Oct 2024 13:31:10 UTC No. 16441153

>>16441130
>Weed back to opioids.

No it isn't you've just need some neuroplasticity, that never happens on opiod withdrawal, to happen. Like 4-ho-met or something simillar, all that mushroom derivates helps to beat addiction.

Literally meth can be useful for opioid withdrawals.

Some people just shouldn't use substances, because they don't know how they work, if you know how they work it's different.

Anonymous at Sun, 20 Oct 2024 13:32:28 UTC No. 16441156

Muh, is ibogaine illegal?

Anonymous at Sun, 20 Oct 2024 13:43:01 UTC No. 16441178

>>16441153
mildly retarded 20 year old ESL detected

Anonymous at Sun, 20 Oct 2024 13:48:43 UTC No. 16441182

>>16441178
Your detectors are faulty, but really I've personally heard from heroine addicts, that meth is way out of opioid addiction.

You maybe don't know what are you talking about, because you're addictologist or similar person who didn't tried speedball and other advanced neural modes of your brain.

Anonymous at Sun, 20 Oct 2024 13:57:32 UTC No. 16441190

>>16441182
Okay, so we hijack the reward pathways with meth or Ritalin instead, and ease the withdrawals with some a2 adrenergic agonism induced release of endorphins. What’s next? Quit the meth?
From experience with you people probably with modafinil aka the most expensive stimulant. How long does that “therapy” endure?
In order to quit these things people eventually need to realise they’re just delaying the inevitable in ways that will make their return to reality much worse (e.g. Steve Johnson syndrome, liver damage, excitotoxic brain damage) it’s much quicker to ditch the pharma kike and handle the shit on your own with nutrition and exercise

I’m also surprised you haven’t mentioned dextromethorphan which has much more potential for treating addictions than methamphetamine, and LACKS the psychological reinforcement, there’s your perfect analgesic there too.
Serotonin syndrome? DXO.

Anonymous at Sun, 20 Oct 2024 14:04:14 UTC No. 16441199

>>16441182
And the words of addicts doesn’t mean shit, especially regarding drug efficacy.
I don’t remember all the times I’ve bullshitted psychs and chemists to get a fix.
“Hows the Ritalin going”
“I took an hour ride on the train, alone.”
“What an improvement!”
Little did he know, that was to get my medical cannabis which was also totally not helping me shoot big loads up my unit walls

Anonymous at Sun, 20 Oct 2024 14:15:41 UTC No. 16441210

>>16441190
You don't even know meth quite differs from ritalin, quite a big lot. You shouldn't do substances.

Anonymous at Sun, 20 Oct 2024 14:23:33 UTC No. 16441217

>>16441210
I know I preferred ritalin, mixes better with alcohol.
Though with regard to pharmacodynamics-
>They’re both sigma 1 agonists
>they’re both 5ht1a agonists
>Both are inverse DAT agonists
Very much the same.

Anonymous at Sun, 20 Oct 2024 14:24:25 UTC No. 16441219

>>16441190
You really don't want to play NMDA card in world of drug addiction.

Anonymous at Sun, 20 Oct 2024 14:30:45 UTC No. 16441228

But they totally different in somewhere about flight or fight...

Anonymous at Sun, 20 Oct 2024 14:37:52 UTC No. 16441237

>>16441219
And why is that, dr GayBiTrans?
What makes DXM unacceptable compared to ketamine?

Anonymous at Sun, 20 Oct 2024 14:44:35 UTC No. 16441249

>>16441237
Ketamine is another NMDA card, you don't want to play.

>>16441217
Do you really think something with 10000 IC50 affects anything?

You can't properly microdose serotogenics most of the time, if you have NMDA antagonist.

Getting regular psilocin dose is necessary for life itself.

Anonymous at Sun, 20 Oct 2024 15:05:09 UTC No. 16441268

>>16441249
>10000 IC50
Ok, Kek got me there, in vivo is yet to be confirmed.
>serotonergics on NMDARA
Yes, won’t work the same. DXM works better for antipsychotic users I suppose
> Getting regular psilocin dose is necessary for life itself.
sounds like the gymnastics of an addict, though I’ve never tried psylosin myself, definitely know some people who haven’t shown any noticeable improvement from it. The LSD experience I had last year seems like an old movie long forgotten.

Most spiritual experiences I’ve ever had were while sleeping with alcohol withdrawal, and that was while on an antipsychotic. Now off the psych meds some good dreams still pop up here and there, I’d say they remove the temptation to try psyllium

Anonymous at Sun, 20 Oct 2024 15:11:12 UTC No. 16441274

>>16441268
Well, as people on AP's we shouldn't really recommend drugs to people based on our personal experience, but there are some that replaces anti-psychotic on receptors. Like binding closer...

Best experience waking up, even thou I don't remember the dream is smoking meth before sleep and right after I wake up. I doubt it can happen with ritalin, it won't let you sleep on day #2 or day #3... It lets you sleep only long after.

Did you know sleep prevents excitotoxicity?

Anonymous at Sun, 20 Oct 2024 15:21:50 UTC No. 16441283

>>16441274
Haha, cool story
> Did you know sleep prevents excitotoxicity?
I was aware It might reduce it, and definitely long term reverse it. But no, I wasn’t aware. Feel free to explain
Something to do with acetylcholine?

Anonymous at Sun, 20 Oct 2024 15:29:09 UTC No. 16441293

>>16441283
Well, maybe the thing you should use with stimulants(amphs and cathiones) is processed dark chocko. It contains that one amino-acid TAAR receptor agonism is indicating you're having, and lecithin in it makes you replenish some metabolites used in acetylcholine storm meth induces.

Anonymous at Sun, 20 Oct 2024 15:38:37 UTC No. 16441301

>>16441293
I see the logic
>dopamine neurons fucked so there’s no AADC
>Take phenethylamine directly just like levodopa
I’d say it’s optimal to abstain, take NRT and consume eggs and milk

Anonymous at Sun, 20 Oct 2024 15:49:04 UTC No. 16441312

>>16441130
>Recommended dose gets you high, it’s supposed - that’s how analgesics work,
no that's not how they work you dumb fucking drug addict. only mind broken addicts think this way.
>then people naturally start seeking out what made them feel good
>t. literal fucking mind broken addict

Anonymous at Sun, 20 Oct 2024 15:59:30 UTC No. 16441322

>>16441312
Picrel
propofol, arguably the most popular analgesic - is dopamine transporter antagonist

Opioids, like porn and amphetamines compromise PFC activity and create memories of reward. if you have an attractive wife and a nutritious diet you’re less susceptible to this kind of behaviour conjuring, it’s still a nuisance though. And every “good” experience on the drug is another reason to justify taking it again- unless you know what’s going on.

Anonymous at Sun, 20 Oct 2024 16:01:35 UTC No. 16441324

>>16441301
They never fuck up so hard. It's quite impossible to get 70mg on kilogram dose, that all those mice studies did.

Anonymous at Sun, 20 Oct 2024 16:11:13 UTC No. 16441330

>>16441322
Selenium prevents picrel, at least acutely. So I suppose if you can find the time to take a dose it would help substantially.
Still, the more you delay the comedowns the more disappointed you’ll be when you inevitably can’t use

Anonymous at Sun, 20 Oct 2024 16:12:14 UTC No. 16441333

>>16441330
>>16441324
Past 2am
Bestowing my resignation for the night

Anonymous at Sun, 20 Oct 2024 16:18:06 UTC No. 16441341

>>16441330
Have you ever asked how mice can inject their meth?

Anonymous at Sun, 20 Oct 2024 17:09:46 UTC No. 16441387

>>16441330
"Spontaneously active dopamine neurons with low firing rates and low burst activity increased in the ventral tegmental area."

This means you can do something on your own. If I ware lab mice, I would also plan escape from lab, meantime pressing the button, because doing things on your own feels good.

Anonymous at Sun, 20 Oct 2024 17:15:06 UTC No. 16441391

Think of people with ADHD, suddenly they learn on their own, if they have that. Because it's good to learn, that activity drives up good behaviour, becuase it releases dopamine... It's how learning works, more dopamine more desired behaviour. I don't want the responsibility, that this society is miseducated, and thinks crime is a good behaving.

Anonymous at Sun, 20 Oct 2024 17:19:18 UTC No. 16441397

Those inhuman monsters even assume that meth is correct. In fact, drugs aren't correct behavior, but lead to one. So that study is pure bullshit.

Anonymous at Sun, 20 Oct 2024 17:32:38 UTC No. 16441409

Here it says sacharin is more dangerous than meth.

Anonymous at Sun, 20 Oct 2024 17:36:59 UTC No. 16441412

https://brieflands.com/articles/ijpbs-90561

And here it's totally not like environment of drug addiction.

You can do nothing else funny depsite playing meth card in the cage.

In real life, you can always have some activity on smartphone or computer...

Anonymous at Sun, 20 Oct 2024 23:45:48 UTC No. 16441892

>>16441322
>create memories of reward
>every “good” experience on the drug is another reason to justify taking it again
this is rarely seen in clinical use settings for pain management (burn patients for example). its really only when certain people self-administer for some sense of euphoria (a side effect they get) that the drug-reward connection gets made.

Anonymous at Mon, 21 Oct 2024 04:04:52 UTC No. 16442142

>>16437664
>Why are opiates still so prevalent?
They aren't. Most prescribers are fearful to use them because of imbeciles like you. For analgesia, most default to NSAIDs or acetaminophen, followed by gabapentioids. Some practices prohibit opioid prescribing altogether and will refer a patient to a pain management specialist.
>Do we really not have a different way of dulling pain?
Of course we do. Why do you lead with rhetorical questions? Opioids are efficacious at removing pain. And yes, there are different ways of achieving analgesia without opioid receptor agonism. Opioids are superior to other pharmacotherapies and the dose can be raised after tolerance occurs. The same cannot be said for non opioid analgesics where peptic ulcers or liver failure or bladder cystitis are certainties with dose escalation.
>Isnt there some electrical impulse device than can dampen pain?
Yes. Spinal cord stimulation, TENS and brain neurosurgery with electrodes have been used with success for analgesia.
>Damn opiates ruined the world cause monkey brains cant handle it
They didn't ruin the world, they improved it by alleviating untold amounts of suffering. Most people who try opioids will not have any euphoria response to them. I have taken them beyond therapeutic doses bordering on respitory depression to no euphoria at all. Something like 1/100 patients will feel energized and happy from it. Most patients will experience extreme nausea, lethargy and even if these are counteracted with 5HT3 antagonists and stimulants, they still won't receive any euphoric effects. The people who abuse opioids are almost exclusively lower IQ indicating higher neuronal density meaning they associate the response with something else, perhaps confused signalling with sexual pleasure. That's why all the junkies typically have tattoos or are black. Dumb people. Small brains. Neurons that light up affect more neurons. Shocker.

Anonymous at Mon, 21 Oct 2024 04:35:47 UTC No. 16442162

>>16441322
Propofol is an anesthetic, not an analgesic. The other stuff is wrong too. Stimulants enhance prefrontal activity and strengthen executive functioning. Opioids do not have much of an effect on prefrontal activity other than lowering seizure threshold, they are certainly nowhere near as harmful to the PFC as weed or alcohol.

Anonymous at Mon, 21 Oct 2024 05:16:24 UTC No. 16442178

>>16438098
>issues only arise when retards try to use them to get high.
There is literally nothing wrong with getting high.

The only thing worse than having your personality being based around drugs, is having your personality being based around NOT doing drugs.

>>16441130
>as the drug compromised their frontal cortex
Is this the brain's version of "...and the front-left of your tongue is where your spicy-food tastebuds are located"?

Anonymous at Mon, 21 Oct 2024 05:45:24 UTC No. 16442190

>>16437664
There are also NSAIDs, but these are probably even worse in long term use.

Anonymous at Mon, 21 Oct 2024 19:04:57 UTC No. 16442934

>>16442190
They are. Ulcers occur with even light use. Kidney damage ensues with chronic use. OP is just an NPC who thinks opioids are the devil.

Anonymous at Mon, 21 Oct 2024 19:17:58 UTC No. 16442951

>>16437664
Opiates saved my life. I had suicidal depression and nothing worked. I tried dozens of meds to no effect. I would just lay in bed and think of ways to kill myself. Then I read an article about treatment resistant depression and opiates that all had amazing results for participants. So I went online and bought some and holy shit they worked amazingly. I was able to get out of bed and enjoy life. I was able to focus for hours on my work when before I would struggle to even get started. I started a career and even got a cute petite Asian girlfriend after starting these drugs.

I've been on them for 15 years now. One dose in the morning and one in the afternoon. They are a miracle drug. Anyone against them are retarded and don't realize they help millions of people. The only reason you see opiates in the media now is because of fentanyl being incredibly dangerous and people having no way to know how much they are taking resulting in so many ODs. Before fent Opiate ODs were a non issue.

You have the DEA rescheduling opiates and limiting doctors ability to prescribe them for the rise of fent. Every decision the DEA does just makes things worse.

>in before some moral fag comes in and tries to dictate how I live my own life.

Anonymous at Mon, 21 Oct 2024 19:26:40 UTC No. 16442969

The American pharma lobby actively gets non-opioid-based painkillers banned all the time.

Novalgin(Metamizol) is one of the most used painkillers in Europe, even the world yet it's illegal and Japan and the US because it's the strongest non-addictive painkiller.

Anonymous at Mon, 21 Oct 2024 19:38:40 UTC No. 16442990

>>16442969
>Novalgin
It's literally just Tylenol. Meanwhile in Canada and the UK you can get Tylenol with codeine. In Mexico, any opiates stronger than codeine are codeine illegal outside of hospitals but you can buy tramadol which is like an opiate and will get you high as fuck but you also risk seizures.

Tramadol is probably the strongest non opiate painkiller you can take and while addictive, not nearly as much as opiates.

Anonymous at Tue, 22 Oct 2024 06:25:30 UTC No. 16443711

>>16442969
Clueless retard. No they don't. Opioids are the most likely to be rejected and almost no pharmaceutical companies bother with developing new ones because they'll be CII and slapped with a manufacturing quota and also have retards like you as AGs making up fake charges because it's politically convenient to blame everything on heckin oid epidemic instead of fixing society.

The reason the drug isn't approved is because pharmaceutical companies cannot patent it therefore lobby against it's approval where a generic from a facility that might already have approval would be stopped in the cradle and nonetheless impose extremely high costs for IND for new drugs and ANDA for generics, which is upwards of tens of millions of dollars in the low-ball end for the latter simply for approvals, inspections.

Blaming it on opioids is a reddit strategy and also is probably done by pharmaceutical companies themselves. Its much easier to have brainlets like you outraged over a straw man, while the real issues of artificial barrier to entry costs, pushing of meme drugs like SSRIs, total fabrication of COVID figures and peddling of misinformation for rushed vaccines from firms already earning hundreds of billions in revenue, all are totally ignored if you have idiots saying BIG PHARMA AND THE OPIOIDS DOOOD. Even the infractions of the preceding involving opioids with marketing reps was dishonest if you consider the majority of opioid prescriptions were generic and even when exclusivity was held by oxycotin with Purdue, only represented a fraction of all opioid prescribing, whereas the latest and greatest SSRI or diabetes drug, has much greater market share and was archived with much more unscrupulous levels of promotions and kickbacks but nobody cares because it isn't about le evil drug that dumb people blame literally everything on.

Anonymous at Tue, 22 Oct 2024 06:44:42 UTC No. 16443725

>>16442990
>In Mexico, any opiates stronger than codeine are codeine illegal outside of hospitals
They are controlled, not illegal. There are pain clinics in Mexico. US patients can fly there, get a prescription, and import up to 60 pills a month if brought over themselves. I would imagine there is some way for 90 day prescriptions to minimize the need for monthly travel, considering their allowance domestically.

That's not enough for a drug addict. A pain patient would benefit from it and could use HSA and FSA funds to it even though insurance wouldn't cover it. No idea on the costs. The FDA has a PDF on the process and what is allowed.

I didn't know about this when I needed them. My car accident injuries are over now. I was in severe pain without access to a prescription and by the time I got one I didn't need it. Doctors who don't write opioids prescriptions for legitimate pain should lose their license. Americans shouldn't need to travel to a shit hole.