Anonymous at Mon, 21 Oct 2024 02:22:48 UTC No. 16442060

>>16442034
https://www.proteinatlas.org/

Anonymous at Mon, 21 Oct 2024 04:06:19 UTC No. 16442144

Committing them to memory? Have perfect information analysis and compartmentalization. Or at least train for it. Then painstakingly learn each component and how it relates to others. Good luck on that. You'd be better off to use reference and work sequentially and take an absurd amount of notes. Use schizo strings to help emphasize connections/relationships. Color code them too.

Anonymous at Mon, 21 Oct 2024 07:45:18 UTC No. 16442254

Step 1 is to modify your own memory to hold more stuff. Nothing like this has been invented yet but Neuralink is promising.

Anonymous at Mon, 21 Oct 2024 11:20:47 UTC No. 16442391

It might be a good idea to learn all the (major) prokaryotic proteins first. Most of them are metabolic proteins which humans don't have, but it gives you a better idea of how cells work and where things came from in general.

I recommend making obsidian notes to keep track of everything. For eukaryotic proteins, the first thing is make sure you view their structures on RCSB or you won't remember shit. Also probably take the time to save the structures in a folder on your computer or save links to them in your obsidian notes so that you can find them with a click of a button.

Eukaryotes have a lot of systems:
GTPases and their GEFs and GAPs
Histones and Remodeler Complexes (archaeal histones formed stacks that were hard to move, which evolved into tetramers that could be moved by helicases and then into octamers)
The Ubiquitin System + Proteasome
The spliceosome (which actually came with the introns themselves, as evidenced by the fact that the main protein is a reverse transcriptase https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078730/)
The Actin system,
The ESCRT system (for cell division and later for packing water filled endosomes with cargo bubbles)
Are among some of the more ancient ones that eukaryotes probably had in the Paleoproterozoic.

Mesoproterozoic eukaryotes were focused on eating bacteria rather than continuing on as their ancestors lived and evolved a bunch more systems.
They got a lot of Serine/Threonine Kinases from bacteria, which they may not have had previously. They evolved mediator to hold back pol II so that a kinase can light up its landing strip of a tail with phosphorylations. That way the 5' capping machinery can quickly mobilize to it at the start of transcription.
This era brought us the mitochondria and culminated in the supremacy of flagellated excavates who probably invented meiosis and the flagella.

For vertebrates it's basically taking all the eukaryotic systems, but there's a lot more signaling between cells involved.

Anonymous at Tue, 22 Oct 2024 02:21:47 UTC No. 16443477

>>16442391
Danke

Anonymous at Wed, 23 Oct 2024 11:23:25 UTC No. 16445577

>>16442391
What drives matter to organize itself into complex self replicating systems ?
Your rhetoric implies an underlying intelligence or motive such as
>They evolved mediator to hold back pol II so that a kinase can light up its landing strip of a tail with phosphorylations
Who evolved it ? Itself ?
The uncaring intelligence of evolution I suppose
This emergent complexity occurs relentlessly, as above so below
Doesn't entropy contradict self-organization by unthinking matter ?

Anonymous at Wed, 23 Oct 2024 11:51:54 UTC No. 16445590

this thread belongs to /fit/

Anonymous at Wed, 23 Oct 2024 12:31:36 UTC No. 16445616

>>16445577
It's one of the top 5 mysteries how this all evolved. Just enjoy the mystery and use your best judgement. It's a pretty fantastic mechanism. One that's appeared only once in the history of the world from what we know. Of course I can only give you the *apparent* reason for it. I'm not a time-travelling wizard. We all know that evolution is an incremental process, and that the real story can be more complex than the way things first appear.

EBOK at Wed, 23 Oct 2024 12:34:22 UTC No. 16445618

>>16445616
Everything is a mystery to the retarded like yourself. Nothing is a mystery to me. Be careful with your words, giganerd.

Anonymous at Wed, 23 Oct 2024 12:39:40 UTC No. 16445621

>>16442034
All fast acting proteins are air based.

Anonymous at Thu, 24 Oct 2024 10:18:15 UTC No. 16446981

>>16442034
suck them out of dicks, as is OP tradition