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Anonymous at Fri, 15 Nov 2024 13:43:13 UTC No. 16476077
Biofags, how big of a deal is this?
Anonymous at Fri, 15 Nov 2024 16:44:36 UTC No. 16476404
bump
Anonymous at Fri, 15 Nov 2024 18:15:53 UTC No. 16476530
>>16476077
good we can cure disease
Anonymous at Fri, 15 Nov 2024 18:24:30 UTC No. 16476555
>>16476077
>melt
I think they mean "mark." Otherwise I dunno what's going on with that.
Anonymous at Fri, 15 Nov 2024 18:46:14 UTC No. 16476597
>>16476077
>Could
>Potentially
begging for investment, no breakthrough as they claim
Anonymous at Fri, 15 Nov 2024 23:31:35 UTC No. 16477054
>>16476077
This has been known for a while hasn't it? Its just made research easier since you can knock out a gene without doing GMO.
Jefferson01 at Sat, 16 Nov 2024 00:36:52 UTC No. 16477201
>>16476077
>original paper
https://www.nature.com/articles/s41
>nuclease independent interference pathway
Don't need to cut the DNA to prevent its expression
>DinG
Seems to be a type of helicase, which splits DNA into two RNA strands
>still uses RNA guide to select which strand to silence
>It improves upon previous knowledge of DinG helicases (https://pmc.ncbi.nlm.nih.gov/artic
> paper focuses on many different cases of DinG, structure, and role
I think it's leading up to something. I don't think they explained how exactly the DinG interferes with transcription, but I was just skimming. They lost me on the results page.
It's something, but not revolutionary. I frankly don't see a use case for this, perhaps in humans where cutting out genes seems too harsh.
I couldn't see DinG's mechanism. Can y'all check for me? Scihub is your friend. Something that explains a mechanism could get a Nobel if the applied technology also is used widely.
Jefferson01 at Sat, 16 Nov 2024 00:38:28 UTC No. 16477208
>>16477201
https://academic.oup.com/nar/articl
Jefferson01 at Sat, 16 Nov 2024 00:41:44 UTC No. 16477215
>>16477201
>I couldn't see DinG's mechanism
Ah, nevermind, it's in discussions. Curse my bad eyes!
Jefferson01 at Sat, 16 Nov 2024 01:03:46 UTC No. 16477264
>>16476077
Okay, take my words with a grain of salt as I am a mere undergrad.
Paragraph 1~2 of discussions section mentions that they need further investigation.
However, my personal hypothesis based on the paper, is that somehow, the DinG helicase going into some target strand again and again interferes with polymerase activity somehow. My 2c.
Anonymous at Sat, 16 Nov 2024 01:10:05 UTC No. 16477277
>>16476077
Ahem, this was discovered by a joint French/Harvard team.