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๐Ÿงต Untitled Thread

Anonymous No. 16581787

how do stem cells distinguish what role they'll take when they differentiate? i understand gene expression is involved here, but isn't gene expression going to be identical for all stem cells? what starts off the differentiation process?

Anonymous No. 16581821

>>16581787
>what starts off the differentiation process?
accelerative force of gravity

Anonymous No. 16581846

>>16581787
>what starts off the differentiation process
They don't know. All they're doing is describing how one substance stimulates or inhibits another substance but they can't find the cause of how the whole is orchestrated in such an orderly and timely fashion.

Cult of Passion No. 16581863

>>16581787
https://youtu.be/Z-9rLlFgcm0

Anonymous No. 16581876

>>16581846
>they can't find the cause of how the whole is orchestrated in such an orderly and timely fashion.
accelerative force of gravity

Anonymous No. 16581883

From my understanding of fetal development basically all humans grow in the same way (anus first), so every split (or every n splits) you can activate different genes, so over time certain parts grow out of others.
As long as genes gradually turn on in the same order, you'd get the same results.

Anonymous No. 16581889

>>16581883
>so every split (or every n splits) you can activate different genes, so over time certain parts grow out of others.
so now you just need a clock to keep count
fortunate, the accelerative force of gravity points downward in one of the four dimensions, we call that one "time"
genes, and the constant clock of time created through the local mass distribution, keep count
1 2 3 4 5
1 2 4 8 16
Every 5-step down time is a 16-fold amount of growth which we call a "growt". Growts are fundamental in that they can not be subdivided. They are the fundamental unit of time. All integer math stems from the tick-tock of time's downward clock.
all the rest is space and is 100% R^3, smooth, and continuous

Anonymous No. 16581970

>>16581889
No.

Anonymous No. 16581972

>>16581970
Iโ€™m on /sci/ for the first time(usually /tv/, just trying to find any discussion on the NIH cuts), are the threads usually 50% schizos?

Anonymous No. 16581974

>>16581787
Epigenetic, external and positional factors.

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Cult of Passion No. 16581989

>>16581972
>are the threads usually 50% schizos
Yes. I come here to correct students on various topics and study mentally ill people.
>any discussion on the NIH cuts
Those "schizos" also have PhDs and work at Harvard and the NIH, they lie and switch lies without a second thought...thats what all the defunding us about. Flushing out corrupted "scientists" and "researchers". When truth doesnt matter...all that matters is what is self beneficial, thats what corruption breeds; liars and thiefs.

>/tv/
Fucking gross...

Anonymous No. 16582019

>>16581972
All the namefags are sub-80 IQ retards, then half the anon are /x/ schizopasters. You also get a healthy share of religious retards and /his/fags in any thread that mentions evolution or consciousness respectively.

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Cult of Passion No. 16582042

Watch, thread, and honored guest (>>16581972), as I reveal this Anon as a mentally ill shitposter talking out of his ass.

>>16582019
>All the namefags are sub-80 IQ retards
What is your field of research, and in what was does it pertain to anatomical morphospace?

Also, notice how the only citable post was mine above, and his work is exactly what OP is asking about, yet no one responded...because they would have to attend lectures, about science...and thats "hard".

Yevgeniy Pillman No. 16582389

>>16582042
Ah Cult of Passion, are you sure you want to have a schizophrenic meltdown in front of new people

Anonymous No. 16582394

>>16581883
>so every split (or every n splits) you can activate different genes,
are you trying to tell me that every single split involving millions of cells is preconfigured to cause a unique differentiation via gene expression from the moment a zygote is formed? how can millions of unique expressions be organized like that from the same set of genome?

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Cult of Passion No. 16582395

Watch, thread, and honored guest (>>16581972 #), as I reveal this Anon as a mentally ill shitposter talking out of his ass.

>>16582389
>Ah Cult of Passion
You dont know me and never post about science, that is the definition of "talking out of one's ass"

>i have a PhD
POST FIELD OF RESEARCH, LETS DISCUSS YOUR THESIS.
>you
>you
>you
I AM YOUR GOD, CORRECT.

Anonymous No. 16582400

>>16582395
you still have that gaymer phone that you play on, you child? oh sorry, docteur

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Cult of Passion No. 16582406

>>16582400
>[snickers] u dum we smart
You are mentally retarded and I am a Doctor of Cognition, this is a diagnosis.

>but im like everyone else
YOU ARE ALL MENTALLY RETARDED. ALL OF YOU.

Yevgeniy Pillman No. 16582409

>>16582395
>You dont know me

I have talked to you long enough I think I know you really well

>I AM YOUR GOD, CORRECT

You wish to be god and larp as a mystical magical being.
Prove me wrong, tell everyone here you know you have no supernatural magic powers, or take meds

Yevgeniy Pillman No. 16582410

>>16582406
Quick reminder that you need to graduate high school and get education after that in order to become a doctor, you cannot drop out in middle school and just give yourself twelve PhDs

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Cult of Passion No. 16582419

>>16582409
>you
>you
>you
>you
>>16582410
>you
>you
>yourself

>>16582395
>>you
>>you
>>you
>I AM YOUR GOD, CORRECT.

TA DA!...its...here.

Yevgeniy Pillman No. 16582428

>>16582419
The Cult of Passion cycle
1. Have a schizophrenic meltdown
2. Pretend to be a tough guy online
3. Pretend to be God on /sci/ <(We are here)
4. Spam gore and poop photographs
5. Get sent back to /x/
6. Get bullied for being a retard on /x/

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Cult of Passion No. 16582437

>>16581787
>how do stem cells distinguish what role they'll take when they differentiate?
https://www.researchgate.net/publication/382242564_Stress_Sharing_as_Cognitive_Glue_for_Collective_Intelligences_a_computational_model_of_stress_as_a_coordinator_for_morphogenesis

>>16582428
>Yevgeniy Pillman
Notice this name NEVER posts about science, EVER...because if she does she will be proven to be ignorant.

SHE ONLY TALKS ABOUT ME, HER GOD SHE REBELS AGAINST (EVE).

Yevgeniy Pillman No. 16582448

>>16582437
>Notice this name NEVER posts about science, EVER

If I have told you thirty times, cult, I have told you three hundred, I only namefag when I made fun of you.

>SHE ONLY TALKS ABOUT ME, HER GOD SHE REBELS AGAINST (EVE).

And I thought you said you have no ego at all, oh false god

Anonymous No. 16582450

>>16582428
kek

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Cult of Passion No. 16582459

>>16582448
>when I made fun of you
Why not tell me what your PhD is in?

YOU SAID "I HAVE A PHD."

IN WHAT?

>>16582042
>reveal this Anon as a mentally ill shitposter talking out of his ass
Revealed.

>>16582450
Your sense of hunor is disgustingly shallow and reveals that you seek quick lies at the expense of reality;
https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2024.1454774/full

This is why Professor Dave is so popular, he spouts lies and people PREFER lies...the People of the Lie need lies to feel powerful, without lies they face reality; their enemy.

>>16581821
>accelerative force of gravity
Schizobabble, an ignored post...because the lies are beneficial to them.

Yevgeniy Pillman No. 16582470

>>16582459
>Why not tell me what your PhD is in?

I will tell you when you get your GED, and seek help for schizophrenia
Fair deal, you dropout

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Cult of Passion No. 16582475

>>16582470
>I will tell you when
>>16582395
>Watch, thread, and honored guest (>>16581972), as I reveal this Anon as a mentally ill shitposter talking out of his ass.

Anonymous No. 16582482

>>16582459
>Professor Dave
cringe, same as your idol Bret Weinstein, brainlets

Yevgeniy Pillman No. 16582486

>>16582475
A) You have supernatural abilities/ are "God, Jesus, and The Vicar of Christ"

Or

B) You are a troll who pretends to have magic powers on /sci/ and /x/

Chose

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Cult of Passion No. 16582488

>>16582482
>your
>>16582419
>I AM YOUR GOD, CORRECT.
>TA DA!...its...here.

Discuss his research of telomeres in medical research rats or shut your cock-hole.

NOTICE THREAD...he discusses how one FEELS (idolization), NOT SCIENCE.

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Cult of Passion No. 16582489

>>16582486
>Chose
Chosen*.

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Cult of Passion No. 16582504

>>16582486
>B) You are a troll who pretends to have magic powers on /sci/ and /x/

I feel sorry for you, so I am going to let you in on a secret, I am a massive troll, I just have nothing better to do with my time
Disregard >>16582488 and >>16582489
It should be obvious that I know I am not "Chosen" or "God"
Do you really think I am retarded?

Yevgeniy Pillman No. 16582505

>>16582504
You got me really good, damn

Anonymous No. 16582508

>>16582504
I'll let you in on a cooler secret: I'm a long-term troll who has lurked so long that I picked up enough information on /sci/entific knowledge to turn into a modern-day alchemist with biochemistry powers beyond those published in the medical journals.

Yevgeniy Pillman No. 16582510

>>16582508
So are you pretty much what he was larping as?

Anonymous No. 16582512

>>16582510
Maybe. I'm on more drugs than Bryan Johnson and discovered an entirely new hair growth treatment, so there is that.

Yevgeniy Pillman No. 16582515

>>16582512
Interesting, tell me more about your abilities and what you have learned

Anonymous No. 16582517

>>16582512
is it hard making ibuprofen at home?

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Cult of Passion No. 16582521

>>16582508
>I'm a long-term troll

Yevgeniy Pillman No. 16582524

>>16582521
I am glad you are, it would be tragic if the "Cult of Passion" character was a real mentally ill person.
I must admit you had me fooled.
I am glad to know you are not some mentally gone retard who thinks he is chosen and believes he has wizard powers

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Anonymous No. 16582527

>>16582515
>>16582517
>>16582521
Making ibuprofen is a waste of time. Aspirin is the least gainz-goblin NSAID. Singlet oxygen is a crazy-ass topical hair growth drug you can't find in pharmacies, but you can find its precursors. NAC, Glycine and astaxanthin are the three best-proven life-extension drugs for humans. Bromelain is one of the most promising that picrel Wax Tranny doesn't know about. He has some copper skill issues too, among many others.

Yevgeniy Pillman No. 16582528

>>16582524
Honestly its good to know that my efforts to get you to seek help were not too little too late, amd you were just fucking with me

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Cult of Passion No. 16582530

>>16582524
>I
>I
>I
What does any of this have to do with anatomical morphospace or cellular cognition?

Why do you NEVER post about science, topics, or anything except ME?

BECAUSE YOU ARE ENTHRALLED.

Yevgeniy Pillman No. 16582536

>>16582504
>>16582521
I hope you are the real Cult of Passion

>>16582530
And you are a troll

It would be very sad if Cult really is an autistic retard with schizophrenia who dropped out of school

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Cult of Passion No. 16582547

>>16582536
>who dropped out of school
"School decides truth."
Appeal to authority (the collective, like a woman), because she has no ability to discern truth on his own.

>>16582511
>Nature counter acts this by offloading "truth verification" to society at large, because if everyone agrees then it likely is true
[taps sign]

She has no ability to perceive reality unless a people with "authority" tell her what to believe, she is a slave.

Yevgeniy Pillman No. 16582559

>>16582547
>Why yes, I did drop out of school, asking me to graduate high school and know the fundamental basics of math or science is an appeal to authority
>How dare you ask me to explain myself about anything, don't you know I gave myself twelve PhDs after watching SciShow on YouTube? Don't you know I am an unquestionable authority on everything ever? Don't you know I am literally God AND Jesus

Delusions of Grandeur and a massive ego.
Classic Cult of Passion

Anonymous No. 16582563

>>16582547
>Appeal to authority
for fucks sake you moron you always point to your fucking phd how clueless are you?

Yevgeniy Pillman No. 16582568

>>16582563
Maybe Cult of Passion IS God, and the reason everything is so fucked up in society, along with space being nearly uninhabitable, is because God is a huge fucking retard.

Anonymous No. 16582586

>>16582568
Cuck of Passion shit god confirmed!

Anonymous No. 16582617

OP here. can't you fags go to a discord or something? stop shitting up my thread with your schizo rambling.

Cult of Passion No. 16582624

>>16582617
>https://youtu.be/Z-9rLlFgcm0
YOU WERE ANSWDED.

YOU HAVE NO INTEREST IN SCIENCE.

GO TO DISCORD TO LARP.

Yevgeniy Pillman No. 16582631

>>16582624
Meds
Now

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Cult of Passion No. 16582639

>>16582631
STOP SHITTING UP THREADS.

>>16582617
Youre fucking retard that attracts lies because youre not looking for science, youre looking for validation in your own ignorance.

Yevgeniy Pillman No. 16582650

>>16582639
>Pretending to be God, lying about everything, falsifying credentials

Not shitting up threads

>Making fun of a liar

Shitting up threads

Sorry cult, I thought constant lying for attention was a bad thing, thank you for setting me straight, I am proud to announce I am the immortal space alien who gifted math to humanity

Yevgeniy Pillman No. 16582892

>>16582639
Fleeing again I see

Anonymous No. 16583053

>>16581787
we dont know lol

Anonymous No. 16583265

>>16581787
That's not super well understood right now

Anonymous No. 16583401

>>16581787
Cell identity is determined by epigenetic encodings.

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Anonymous No. 16583486

>>16581787
>The initiation of differentiation involves several key mechanisms working together:
>Growth factors and signaling molecules from neighboring cells
>Environmental cues like temperature and oxygen levels
>Secreted proteins that trigger specific pathways
>Epigenetic modifications (chemical changes to DNA and histone proteins)
>Specialized transcription factors that bind to specific genes
>Chromatin structure changes that affect gene accessibility
>What makes stem cell differentiation particularly sophisticated is how these signals converge. Research shows that embryonic cells exist in a unique epigenetic state with "bivalent domains" - regions that can quickly respond to either maintain stemness or initiate differentiation
>Differentiation can be triggered by various events:
>Changes in environmental conditions
>Signals from surrounding cells
>Developmental timing cues
>Experimental induction (like using retinoic acid in lab settings)
>The beauty of this system lies in its complexity and precision. Rather than having identical gene expression patterns, stem cells constantly monitor and respond to their environment through subtle variations in gene activity. When the right combination of signals arrives, the cell begins its journey toward specialization, guided by both external cues and internal regulatory mechanisms.

Anonymous No. 16583726

Another thread that is conveniently dancing around the topic of Apigenic Health. Sad.

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Anonymous No. 16583913

>>16583726
Even the thread on upgrading Bryan Johnson's stack got fully hijacked into one on Apigenic health, and poor Bryan Johnson's Chud lines just keep getting worse and worser.
>protip: topical methylene blue is one of the top anti-aging skin research chemicals he doesn't know about, it stains for days though!

Anonymous No. 16583923

>>16581787
There are genes that code for where certain cells should go, and cells express different genes depending on where they are

Anonymous No. 16584266

>>16583913
He literally can't take it or talk about it because of the censorship dude. Think about it.

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Anonymous No. 16584408

>>16584266
You're sure he's not maybe... scared of dying teratomas still, or just has skill issues? He has enough skill issues with chemoprophylaxis anyway, it would not surprise me if none of his thirty boomer doctors even got on this board.

Anonymous No. 16584529

>>16584408
He pays people to find things like this. It went all over Denver.

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Anonymous No. 16584537

>>16584529
>He pays people to find things like this.
he can't find copper or chromium supplements, or protease enzymes, or ergothioneine or methylene blue to name just a few. he found rapamycin instead of meclizine and regretted that. he found IPL, found a bunch of expensive derma-gadgets he no longer uses, and can't find any photodynamic chemo. that only even scratches the surface of some areas of biohacking I personally know better than him.

>I see MANY LEVELS of skill issues.