🧵 Can i get a parley on the nothing ever happens train?
Anonymous at Sat, 15 Mar 2025 16:03:41 UTC No. 16619791
>before, converting skin cells into neurons meant a messy detour through induced pluripotent stem cells (iPSCs). slow, inefficient (~1%), and cells often got stuck half-way, wasting weeks and resources.
>MIT's breakthrough bypasses the iPSC bottleneck entirely. they tweaked the conversion cocktail down to just 3 transcription factors (Ngn2, Isl1, Lhx3) plus two genes boosting proliferation, sending neuron yield to over 1000%.
>researchers engineered skin cells from mice using a single retrovirus to deliver these factors, ensuring precise expression levels in each cell. simpler method, fewer errors, massive efficiency.
>cells were pushed into hyperproliferation first, dramatically increasing their receptivity to the transcription factors. basically, MIT primed cells into a hyper-responsive state before flipping the neuron switch.
>hyperproliferation boosts conversion success by 4x. cells aren’t just more numerous, they’re also more receptive. conversion is faster (just two weeks), yielding morphologically mature motor neurons ready to be used
>the most impressive data point is that the yield jumped from below 1% with old methods to 1100% with this new cocktail. over ten neurons per single original skin cell.
>neurons implanted into mouse brains survived and integrated, showing electrical activity and calcium signaling.
https://www.sciencedirect.com/scien
Anonymous at Sat, 15 Mar 2025 17:32:12 UTC No. 16619881
>>16619791
Membership goes from 0 to 1.
>infinite growth!!!!! imagine the potential!!!!!
Anonymous at Sat, 15 Mar 2025 19:16:16 UTC No. 16619977
>>16619791
And the cancer?
Anonymous at Sun, 16 Mar 2025 04:42:46 UTC No. 16620402
>>16619791
Literally Batman Beyond episode 1 of season 2
Anonymous at Sun, 16 Mar 2025 07:55:35 UTC No. 16620538
>>16619977
Is cancer the big filter of biology?
>Cant tamper with the human body
>Or its organs
>Or its genome
>Without potential new cancers manifesting down the line
There's literally no way to do anything, nor a solution to this wall.
Anonymous at Sun, 16 Mar 2025 12:51:24 UTC No. 16620682
>>16620538
>nor a solution to this wall.
to cure cancer all you need is to figure out how to target specific cells within a human body with zero or minimal side effects. we already have dozens of ways how to do it
>cut it out with scalpel
>burn it out with lazors
>burn it out with radiation
>poison it out via chemo
>reprogram immune system so it targets the canver cells
>inject custom made "immune cells" preprogrammed to seek the cancer cells
>shut down cancers feed supply and starve it to death
honestly as time goes on, the toolkit we have to treat various types of cancer is growing steadily. few decades ago even diagnosing cancer was akin to performing horoscope, nowadays we can detect it in early stages just from blood tests.
i believe in a few centuries cancer will be as dangerous as flu nowadays: you will go to doc, he will throw at you penicilin equivalent for cancer treatement, you will cough up 10$ for bottle and resume working for goldstein.
Anonymous at Sun, 16 Mar 2025 13:28:25 UTC No. 16620711
>>16620682
Biology will never be a science precisely because there will always be heavy side effects both in the short term and long term. There's not enough homogeneity among the humans and there's not enough reproducibility in biology for it to be a science. And this it will be always a huge dud.
Anonymous at Sun, 16 Mar 2025 14:23:20 UTC No. 16620736
>>16620682
>to cure cancer all you need is to figure out how to target specific cells within a human body with zero or minimal side effects. we already have dozens of ways how to do it
antibody therapy with short lived actinides arent sufficient?
Anonymous at Sun, 16 Mar 2025 16:25:28 UTC No. 16620905
>>16620538
What's stopping us from examining the altered genome of the cancer, finding the affected genes and shutting those genes off to return the cells to normal?
Anonymous at Mon, 17 Mar 2025 12:45:33 UTC No. 16621583
>>16620736
that is the
>inject custom made immune "cells"
option. however as it is now its expensive, slow and not all purpouse, some cancer it works well, some not so much. but unlike the cold fusion science bros with their
>just two more weeks!
the medicine field is actually progressing somewhat forward and as the cure gets into mass production, so does its price goes down. so in some decades later you really could have machine at doctor, where you put in your blood sample and it will spit out your custom anti cancer pill for a couple dollars.
so far the hardest part of curing the cancer is finding mechanism which targets ONLY the cancer and keeps rest of the patients body alive, or at least in state which isnt terminal. a lot of drugs were super promising in the past, except they destroyed patients livers for example. same goes with anti cancer treatements research: sure this X kills cancer cell under 24 hours, but it also kills patient in 48 hours.
Anonymous at Mon, 17 Mar 2025 13:53:29 UTC No. 16621602
>>16621583
Let's all in fuck her
Anonymous at Mon, 17 Mar 2025 20:07:25 UTC No. 16621853
>>16619791
>100-fold
weebs get out
Anonymous at Mon, 17 Mar 2025 21:37:08 UTC No. 16621931
>>16620538
It’s entirely possible that there are better ways of organizing genetics and immune response so that cancer never happens or is a non issue. In fact I’d say it’s likely or even certain, if you consider that some animals have long lifespans and cancer resistance.
Imo the “great filter” of biology is the inherent fragility of biological molecules. There’s no way to get around the fact that cells are tiny sacs full of water and relatively unstable compounds. Heat, cold, radiation, shock, mechanical force, chemicals, almost anything in the universe can seriously harm or kill us. Our bodies are balanced around an extremely particular environment, and I don’t think we can ever really change that on a biological level. Hell, most people live in a place that would kill them by temperature alone if they didn’t have fire and clothes. We will never have the strength and certainty of steel.
Anonymous at Tue, 18 Mar 2025 01:29:43 UTC No. 16622115
>>16621583
Tracking dot.
DoctorGreen !DRgReeNusk at Tue, 18 Mar 2025 19:56:30 UTC No. 16622610
>>16622115
just