Anonymous at Fri, 28 Mar 2025 05:37:29 UTC No. 16630566

>>16630518
Depression meds usually dont work regardless of circumstances, at least not long term - serotonin ends up suppressing limbic/reward system dopamine neuron firing destroying motivation leading to downstream circumstances like malnutrition and poor physical ability (body image) typical prolactin elevation would also play a role.

The “antipsychotics” or neuroleptics by directly suppressing dopamine transmission, either through a1 adrenergic, 5ht2b, or direct dopamine activities lead to sensitisation of various dopamine-regulated systems producing a rebound once the drug is discontinued (not always full blown psychosis, but delirium and mental instability- experienced myself)

The functional dopamine antagonists reliably reduce inherent behaviours like focusing and progressing your interests, could relate to mastering skills which is related to functional dopamine antagonism in the PFC - dominant area for reasoning, self-regulation and directing your focus.

Anonymous at Fri, 28 Mar 2025 05:40:06 UTC No. 16630571

>>16630566
Its disturbing where this stuff can take people, especially when its used to reduce ultimately victimless or behaviours that could be rectified through minor changes to the external factors in their life.

Anonymous at Fri, 28 Mar 2025 06:37:22 UTC No. 16630611

>>16630566
>producing a rebound once the drug is discontinued
wouldn't that happen if i did anything that gave a big dopamine hit?

Anonymous at Fri, 28 Mar 2025 06:56:52 UTC No. 16630627

>>16630518
it would be extremely painful

Anonymous at Fri, 28 Mar 2025 07:04:31 UTC No. 16630634

>>16630611
The drugs in question “antipsychotics”
There are some factors like low dose preferential auto-receptor antagonism but the dominant mechanism - they only really have appreciable blocking at d2-like receptors which consist of d2, d3, d4 - when activated these receptors are inhibitory on adenylate cyclase (decline in neurotransmission) - the typical sedation if selective for d2-like arises from inhibiting dopamine’s regulation from sleep/wake pathways, motivation and reasoning.

Drugs like amphetamines, hit all 5 classified dopamine receptors (including autoreceptors which can be preferentially blocked by quetiapine for example to further dopamine release - though youd have to be insane to do this in your right mind)

The supersensitivity arising from chronic d2 block produces issue like tardive dyskinesia (within nigrostriatal pathway- also acute akathisia common for fucking with dopamine and acetylcholine balance in this area too but only really apparent whilst under influence.) and supersensitivity psychosis is usually attributed to sensitivity in mesolimbic areas but pfc likely involved - not just d2, the aforementioned 5ht2b and a1 (particularly a1b adrenergic) too

Anonymous at Fri, 28 Mar 2025 07:11:36 UTC No. 16630640

>>16630634
Funny, I did encounter quite a few coincidences too good to label as such coming off those meds

Anonymous at Fri, 28 Mar 2025 07:18:42 UTC No. 16630645

>>16630640
Nevermind. Deeper biological meaning. Closing the retard closet, been less than 2 months since i got myself back.

Anonymous at Fri, 28 Mar 2025 07:32:13 UTC No. 16630654

>>16630634
seems like these are side effects that the people who rightfully take the medication would also experience. i'm more interested in the immediate effects of taking schizo medication when you don't need to. do you stop being able to imagine things?

Anonymous at Fri, 28 Mar 2025 07:48:30 UTC No. 16630661

>>16630654
I couldn’t get lost in my mind, entertain myself with own thoughts or do fun original wordplay e.g. creating analogies for issues like a can now, and sort of could during my 18 month sobriety gap after amphetamine use at 16 - nutrients weren’t involved at that time, hitting adequate of all essentials now.

Under influence of brexpiprazole and fluvoxamine-
I would insatiably consume cannabis to get lost in my mind, make time pass easier - limbic dopamine suppression is associated with time passing slower - felt like a chore doing tasks that are essentially automatic now..

Id drink copious alcohol when couldn’t obtain cannabis, it became daily for at least 2 years - been on acamprosate, used detox services multiple times, rehab once.

And id use (inhalation) meth near-daily to motivate myself, become sociable, but would more often self-gratify for hours

Anonymous at Fri, 28 Mar 2025 07:49:53 UTC No. 16630662

>>16630654
Its a “cant be fucked thinking about it” kinda feeling

Anonymous at Fri, 28 Mar 2025 07:51:46 UTC No. 16630665

>>16630627
For you.

Anonymous at Fri, 28 Mar 2025 07:51:59 UTC No. 16630666

>>16630662
But alleviating the akathisia with other drugs can become a priority when your reasoning is compromised

Anonymous at Fri, 28 Mar 2025 08:01:06 UTC No. 16630668

>>16630661
i see, then i suppose it would give me adhd to take something like brexpiprazole if we go by the current idea of adhd being a dopamine deficiency

Anonymous at Fri, 28 Mar 2025 08:11:19 UTC No. 16630671

>>16630668
Its tricky
I think very general/blanket terms like ADHD are dangerous, as other cognitive styles - like my mild-moderate asperger can be mistreated under the diagnosis

The general dopamine deficiency claim, although it probably has a bit more depth than low dopamine - as in nigrostriatal would cause parkinsonsim, is hard to believe as testing strategies for nutrient availability could be improved.

But yes, except there isn’t really any silver lining to the antipsychotic induced “adhd” - not really any inherent behaviour left once dose beyond a certain point - they are a punishment drug, even if doesn’t appear so initially.

Anonymous at Fri, 28 Mar 2025 08:18:49 UTC No. 16630676

>>16630671
yes adhd is over-diagnosed in this world where baseline dopamine is pretty high with the constant internet access, but it makes sense that i would start developing more compulsive behavior if i crashed my dopamine since every small action would give me a reward hit

Anonymous at Fri, 28 Mar 2025 08:20:58 UTC No. 16630677

>>16630671
Slightly misworded this
> The general dopamine deficiency claim, although it probably has a bit more depth than low dopamine - as in nigrostriatal would cause parkinsonsim, is hard to believe as testing strategies for nutrient availability could be improved.

It is likely there are specific brain regions where dopamine transmission is declined in individuals complaining of ADHD symptoms - but it cannot be reliably ruled out that a different route wouldn’t be more efficacious or sustainable (nutrition, cessation of porn, ceasing alternate drugs like caffeine, cannabis)

The solution for children according to me would be - they request aid in attending school themselves, not the parents - facilitate inherent behaviour, if the kid doesn’t give a fuck - their psychology is most likely going to demand dosing beyond recommended - obviously use common sense ensuring the more fundamentally important essentially nutrients are adequate first before considering a drug.

Anonymous at Fri, 28 Mar 2025 08:22:45 UTC No. 16630679

>>16630676
Pointless reward seeking impairing executive functions is real

Anonymous at Fri, 28 Mar 2025 08:28:49 UTC No. 16630685

>>16630677
now i have to wonder why doctors think limiting dopamine is the treatment for schizophernia. doesn't seem like those two things are related or else a lot more people would be insane from easy access of internet, addictive food, and other dopamine sources

Anonymous at Fri, 28 Mar 2025 08:29:08 UTC No. 16630686

>>16630676
On the antipsychotics, although many other variables involved, though these ultimately a result of being under their influence- great decline in ability to productively proccess/manage emotions - endless dwelling on the past, working myself up. - some of the mental health “professionals” I’ve encountered did take advantage of and exploit that to further their ultimately psychotic narratives

Anonymous at Fri, 28 Mar 2025 08:34:26 UTC No. 16630690

>>16630685
Theres lots of other hypothesis for schizophrenia, including NMDA hypo-function

The THC in cannabis, by activating CB1 cannabinoid receptors, downstream suppresses NMDA activation by internalising the receptors, sigma 1 agonists like fluvoxamine rescue the receptors from internalisation - some case reports suggesting fluvoxamine can provide acute relief from delusion or psychotic behaviours though some endogenous neurosteroids are sigma 1 agonists too - again, nutrients.. likely differing mechanisms behind each individuals symptoms, using multi-target or “shotgun” approaches creates a mess

Anonymous at Fri, 28 Mar 2025 08:37:28 UTC No. 16630697

>>16630690
how would you combat that purely from nutrition?

Anonymous at Fri, 28 Mar 2025 08:48:59 UTC No. 16630704

>>16630697
For someone already full-blown - not entirely sure
Id start with an approach based on individual autonomy, honesty, freedom of choice - otherwise id be feeding their problem.

Would gradually introduce all essentials to adequate levels - unsure as of now on order but probably raise calcium for example (excitatory) after an increment of everything else. Wouldn’t indulge their psychological problems but acknowledge any stuff that we honestly can’t disprove as what it is, uncertain, attempting to ((honestly)) find a common ground, then once nutrients are at least adequate - begin taper of any and all acquired drug dependences

If improvement, advise and substantiate claims of activities to further enhance their self-regulating frontal cortex (exercise, polyphenols, quit reward seeking).


If to no avail, dunno, guess it would depend on their circumstance, if they haven’t physically harmed or threatened anyone while not under influence of something - i ideally wouldn’t be speaking to them.

Anonymous at Fri, 28 Mar 2025 08:57:28 UTC No. 16630709

>>16630518
Not a doctor but a schizo
I assume you would get all of the shitty side effects with none of the benefits for some medications, others would throw you into inbalance

Anonymous at Fri, 28 Mar 2025 09:00:42 UTC No. 16630712

>>16630704
but what are the specific foods that would reduce the chance of this happening? i imagine that the schizos from over a hundred years ago did not get it from drug abuse, and they were working much more which would be their exercise..

Anonymous at Fri, 28 Mar 2025 09:10:31 UTC No. 16630719

>>16630712
Over a hundred years ago people were supposedly burned for witchcraft too. The word “schizophrenia” is ultimately a label provided by a person who has their own quirks whether publicly admit it or not - could be a thief, a pedo, a crossdresser for all we know - we can only come to conclusions from our own observations, up to us the level of trust we bestow upon other people.

Various individual nutrients hard to obtain in adequate amounts from food, even if estimating optimistically - picrel one example, choline is another - got to eat eggs everyday (continuous shortage in my country) otherwise i’ll eat chicken liver intermittently (intermit because contained excess vitamin A conflicts with my multivitamin molybdenum source)

Anonymous at Fri, 28 Mar 2025 09:25:23 UTC No. 16630723

>>16630719
>pic
interesting. but eating eggs would probably lead to less supply of molybdenum because of the high amounts of sulfur you need to metabolize. i know that some people eat lecithin for choline, so you can eat snoybeans for that

Anonymous at Fri, 28 Mar 2025 09:33:43 UTC No. 16630726

>>16630723
Ideally i’d get the molybdenum adequate enough for my body to adapt producing the tolerance to the sulphites necessary to obtain adequate choline without consuming basedbeans - picrel (not all are ER agonists)

Anonymous at Fri, 28 Mar 2025 09:38:39 UTC No. 16630728

>>16630726
Welp, based always was a bit of a onions “rely on others for approval” kind of word, take it /sci/.

Anonymous at Fri, 28 Mar 2025 09:41:01 UTC No. 16630730

>>16630728
i'm going to bed, but take my basedbean filter bypass as a thank you

Anonymous at Fri, 28 Mar 2025 09:42:02 UTC No. 16630731

>>16630730
nevermind they patched it

Anonymous at Fri, 28 Mar 2025 09:44:45 UTC No. 16630733

>>16630728
No worries, pleasure
Enjoy